Funnels, pathways, and the energy landscape of protein folding: A synthesis
نویسندگان
چکیده
منابع مشابه
Funnels, pathways, and the energy landscape of protein folding: a synthesis.
The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and understood by taking a statistical approach to the energetics of protein conformation, that is, to the energy landscape. The statistical energy landscape approach explains when and why unique behaviors, such as specific folding pathways, occur ...
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The folding pathway and rate coefficients of the folding of a knotted protein are calculated for a potential energy function with minimal energetic frustration. A kinetic transition network is constructed using the discrete path sampling approach, and the resulting potential energy surface is visualized by constructing disconnectivity graphs. Owing to topological constraints, the low-lying port...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1995
ISSN: 0887-3585,1097-0134
DOI: 10.1002/prot.340210302